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All eight infants in the study showed normal growth and development with no adverse effects during 3 to 9 weeks of maternal semaglutide use

44, 77 Methymalonic acid, a metabolite of PPA, results in abnormal mitochondrial morphology, 78 tissue specific ETC dysfunction, 79 inhibition of the complex I and II function when interacting with complex III in the brain 80 and reductions in reduced glutathione, 78 similar to the patient cohort presented and the PPA animal model

The alteration in the production of lipid hydroperoxide triggered by ROS can be determined by the level of MDA