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These medications cut appetite so sharply that many people struggle to eat enough protein, and that puts muscle at risk alongside the fat you want to lose

Accumulating data support the systemic benefits of semaglutide (and potentially other GLP-1RA-based therapies) in people with obesity, meaning that cardiologists and other clinicians must become familiar with prescribing them particularly once market competition makes these drugs more accessible

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Clin Pharmacokinet 57(10):13131328

Investigators reported a 38% higher risk of kidney cancer in GLP-1 users compared to non-users, noting that while the result was marginally nonsignificant, it remains concerning due to the widespread use of these drugs