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In individuals with obesity, at a daily dose of 50 mg, it achieved a 17.4% reduction in body weight over 68 weeks of treatment in the OASIS 1 trial37 (Table 1), attributed to its appetite-suppressing and satiety-enhancing effects

The injectable versions are taken as a weekly self-administered subcutaneous injection

Banerjee M, Mehr R, Belelovsky A, Spencer J, Dunn-Walters DK

Large-scale trials have not shown increased rates of thrombotic events compared to placebo, and the FDA prescribing information does not list blood clots as a recognized adverse effect

In adulthood, PYY is mainly found in , , and PP cell subpopulations of the pancreas (17, 19, 20)