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However, other pathophysiological modifications within melanoma cells may contribute to therapy resistance [4, 5], demanding for large-scale computational models to simulate the complex physiology of a tumour in an integrated manner and comprehensively foster the identification of alternative therapeutic vulnerabilities applying high throughput in silico approaches [6, 7]

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Elevated iron levels are also linked to oxidative stress and ferroptosis, a programmed cell death dependent on intracellular ferrous iron and impaired antioxidant defense systems (Ward et al., 2022)

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