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While direct receptor binding affinity remains an area of ongoing investigation, experimental evidence indicates that AOD 9604 enhances 3-adrenergic receptor expression and signaling capacity in adipose tissue models

[DOI] [PubMed] [Google Scholar] 125.Chatterjee S., Rhee Y., Chung P.S., Ge R.F., Ahn J.C

Two of these case series suggest that dosage may be of importance, with individual differences and higher doses more effective than lower ones where dose was titrated up (dosage ranges 6001800 mg per day)

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Furthermore, catalpol can inhibit the ubiquitination and degradation of PTEN, block the NF-B and AKT signaling pathways, and prevent the differentiation of bone marrow-derived macrophages (BMMs) and RAW264.7 cells induced by receptor activator of nuclear factor kappa-B ligand (RANKL) into osteoclasts