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Semaglutide is sometimes used in combination with metformin, increasing the anti-inflammatory and anti-fibrotic effects [2,8], and significantly improving liver inflammation and fibrosis in people with non-alcoholic fatty liver disease [8]

Some research suggests discontinuation rates for GLP-1s may be significantly higher in the real world, particularly in people with obesity

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Karasik saidthat study participants with lower adherence, in general, will see their glucose levels rise with time, and this was observed in the study

This can cause extra calories to turn into fat, leading to weight gain