reports honoraria and/or consulting fees from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Novartis and Novo Nordisk
Yes, both medications are equally effective because they share the same active ingredient: semaglutide
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Extending the liver program into cirrhosis Because people with advanced liver disease are usually excluded from early trials, a separate Phase 1 study specifically examined survodutide in cirrhosis an important gap-filler for a liver-directed drug
The most commonly reported adverse effects in the Phase 2 clinical trial include: Nausea and vomiting particularly during dose escalation Diarrhoea and constipation Decreased appetite (which contributes to weight loss but may also raise nutritional concerns) Injection site reactions Increases in resting heart rate a signal consistent with other medicines in this class In addition, based on the known class effects of GLP-1-based and incretin therapies (as documented in the Summary of Product Characteristics for licensed comparators such as semaglutide 2.4 mg [Wegovy] and tirzepatide [Mounjaro]), the following risks are relevant to consider in the context of retatrutide's development: Gallbladder disease (including gallstones and cholecystitis) a recognised risk with rapid weight loss and GLP-1 receptor agonism Pancreatitis a potential signal requiring monitoring
