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The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg

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** The presence of a single end-stage chronic illness, such as stage 34 congestive heart failure or oxygen-dependent lung disease, chronic kidney disease requiring dialysis, or uncontrolled metastatic cancer, may cause significant symptoms or impairment of functional status and significantly reduce life expectancy

Q: What happens if I increase my dose too quickly

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