P-38 Impact of sex on the course of hereditary angioedema due to C1-inhibitor deficiency Hanga Rka Horvth, Lili Voloncs-Mindszenthy, Henriette Farkas Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary Allergy, Asthma & Clinical Immunology 2025, 21(Suppl 2) :P-38 Background: Although hereditary angio-edema (HAE) due to C1-inhibitor (C1-INH) deficiency (HAE-C1-INH) is inherited in an autosomal dominant manner, several reports have been published on female predominance in this disease (1, 2)
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In agreement with these latter results, the work of Majors et al (1997) showed that a relatively low concentration of homocysteine (50 to 300 mol/L) stimulates collagen production in rabbit aortic smooth muscle cells that may favor extracellular matrix component accumulation in intimal lesions
