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Additional evidence for an independent intrarenal RAS included observations that intrarenal ANG II contents markedly increased compared to circulating levels

2019;10:969 Westfall S, Caracci F, Estill M, Frolinger T, Shen L, Pasinetti GM

There is also a direct influence of this virulence factor on host IECs through nuclear factor-kappa B (NF-B) activation leading to the redistribution of TJ components including claudin-1, occludin, and E-cadherin (Drolia et al

In the presence of oxygen, pyruvate is then transported into the mitochondria where it is oxidized to acetyl CoA, which enters the Krebs, or citric acid cycle in the mitochondrial matrix