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Results showed statistically significant reductions in body weight and body fat percentage in the AOD9604 treatment groups compared to placebo, with the highest dose producing average fat mass reductions of approximately 2.6 kg greater than placebo

FIGURE 4 To confirm the results at the cellular level, we also detected the phosphorylation levels of Akt and GSK-3 in the back skin of each group (Figure 5A), as well as the translational expression of -Catenin and Wnt10b (Figure 5B)

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In mammals, pathogenic effects of ribosome haploinsufficiency include Diamond-Blackfan anemia and 5 q- syndrome (a hematological disorder) [75]

Standard dosing is 2.4mg weekly via subcutaneous injection, titrated slowly over 12-16 weeks