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The benefits of weight loss in patients with T2D are substantial and are apparent with as little as 5% weight loss

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The CV benefits of the SGLT2 inhibitor on HF and CV death (primarily driven by HF) are observed with months and most likely are hemodynamically driven (simultaneous reduction in preload and afterload), while those of GLP-1s on MACE take 12 to 16 months to be seen and most likely are related to the drugs antiatherogenic effects