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At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems
Chen WR, Hu SY, Chen YD, et al
& Pfleghaar N
The medication's effects on glucose regulation and appetite suppression diminish after discontinuation, as the drug has a half-life of approximately five days, meaning it clears from the system within several weeks
For weight management medications, NICE guidance specifies different stopping rulesfor example, Wegovy treatment should be reviewed after 6 months, and Saxenda should be discontinued if less than 5% weight loss is achieved after 12 weeks at the maintenance dose
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