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PMID: 17279201

The first generation of weight loss drugs focused on stimulant effects or blocking fat absorption, approaches that produced modest results with significant side effects and safety concerns

Simeon 2000 Life Sci simultaneously documented the stimulation of matrix repair and the suppression of degradation by MMP-2 and MMP-9 (matrix metalloproteases), a unique profile of constructive rather than destructive remodelling

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Semaglutide also improved blood sugar, blood pressure, and other health risks, making it especially helpful for people with type 2 diabetes or health problems linked to extra weight