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Maintaining brain health is crucial for overall well-being and longevity, as cognitive decline can profoundly impact physical health, independence, and quality of life

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It is important to clarify that, whereas population-level PRS models require formal effect-size modeling, linkage disequilibrium correction, ancestry calibration, and validation across large cohorts, the score used in this workflow is a functional polygenic score (PRS-F) designed for mechanistic, individual-level interpretation rather than for epidemiological prediction