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No increased risk of pancreatitis, diabetic retinopathy complications, or major cardiovascular events was observed, though longer-term safety data continues to accumulate

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Cardiovascular and Kidney Outcomes No dedicated prospective RCT has yet been powered to compare combined SGLT2i and GLP-1RA therapy versus monotherapy for cardiovascular and kidney endpoints, although the ongoing PRECIDENTD trial is expected to address this gap [36]

Ozempic was approved for the treatment of type 2 diabetes in 2017

The elevated insulin levels also have an effect on the conversion of male hormones into estrogen in the fatty tissues