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Preclinical Research Is Not Clinical Proof Animal and laboratory studies can help researchers form hypotheses, examine biological pathways and decide whether further investigation is justified

To date, eight different variants, including three frameshift mutations (37.5%), two missense mutations (25.0%), one nonsense mutation (12.5%), one copy number mutation (12.5%), and one six-base in-frame deletion (12.5%), have been reported in China in 10 patients from nine unrelated families (Table 1)

This Review summarizes current knowledge of the biology of prolactin and its receptor, as well as its physiological and pathological roles

Stiffness after rest that loosens up with movement is a classic feature