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CAFs and ROS engage in two-way cross-talk: on the one hand, fibroblasts are targeted by ROS, particularly H 2 O 2 , which is able to convert them into active CAFs through the upregulation of HIF1

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Moreover, NGAL binds to the MMP-9, slows its degradation, and enhances collagen degradation.133 Plasma NGAL at discharge predicted 30-day outcomes in patients admitted for acute HF even more strongly than did NT-proBNP.134 In the TOPCAT biomarker sub-study, NGAL level tended to be associated with death or HF admission but this association lost significance upon multiple comparison ( Table 3 ).116 Cystatin-C Cystatin C (CysC) is secreted by nucleated cells at a constant rate, filtered and reabsorbed by the glomeruli, and then completely decomposed by intact renal tubules.134 CysC provides a more sensitive and accurate method for estimated glomerular filtration rate (eGFR) measurement: serum CysC reflects the GFR, while urine CysC reflects the degree of renal tubular damage

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