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IGF-1 also plays a key role in maintaining epidermal homeostasis, helping to prevent skin aging and maintain a youthful appearance (Tavakkol et al., 1999)

in: PubMed | Google Scholar 1 Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada

This difference was achieved without any change in food intake, suggesting the weight loss came from metabolic changes rather than appetite suppression