Pharmacologic activation of this pathway by metformin amplifies Treg populations (104), while glycolysis inhibition with 2-deoxyglucose (2-DG) shifts metabolism toward FAO, thereby promoting a phenotypic switch from Th17 to Treg cells ( FAO-driven OXPHOS is necessary for Treg cells to continue their suppressive role (105)
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McCartney, M
CYANOCOBALAMIN Cyanocobalamin is a synthetic form of vitamin B12 made in a lab
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