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Neuroendocrinology 50:489-494 Kern A, Grande C, Smith RG

This distinction arises because men and women have different hormonal requirements, body compositions, and reactions to growth hormone treatments

Cost-benefit analysis helps assess whether continued annual therapy provides sufficient value relative to investment

Experimental models show that this dual activation can influence both the magnitude and temporal pattern of growth hormone signaling, providing a framework for studying receptor synergy and signal integration [6]