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Improvement of mitochondrial dysfunction is also expected to improve the disordered signal transduction that affects cellular death process, such as Bax and caspase activities (Liu et al., Mitophagy plays an important role in maintaining mitochondria homeostasis by eliminating damaged or dysfunctional mitochondria

Feed intake and feed efficiency were not affected, but oral lesions were apparent on day 7

This organelle-centric vulnerability is further exacerbated by cigarette smoke, which perturbs inter-organelle communication and creates a pro-ferroptotic microenvironment

Berman E, Adams M, Duigou-Osterndorf R, Godfrey L, Clarkson B, Andreeff M