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Although alterations in genetic factors have been linked with its etiology, exponential accumulation of environmental entities such as reactive oxygen species (ROS) initiate a cyclic chain reaction resulting in accumulation of cellular inclusions, dysfunctional mitochondria, and overwhelming of antioxidant machinery, thus accelerating disease pathogenesis

In order to further characterize this effect, -Glu-Glu was then tested on cells expressing either of GluN1 and GluN2A or GluN1 and GluN2B NMDAr subunits, bearing in mind that they are the most abundant NMDA receptors found in the hippocampus ( NMDA receptors were expressed first in astroglioma C6 cells

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Most doctors will prescribe B12 injections, although there is evidence that oral B12 is adequate