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L-carnitine theoretical contribution to muscle preservation is indirect

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The earlier SUSTAIN dose-finding studies for diabetes (Nauck et al., Diabetes Care, 2016) tested multiple dose levels including 0.05 mg, 0.1 mg, 0.2 mg, 0.3 mg, and 0.4 mg daily (note: daily, not weekly) of oral semaglutide and found dose-dependent reductions in HbA1c and body weight at every dose tested

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Retatrutide's data come from approximately 338 obesity trial participants followed for 48 weeks

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At the same time, ICER did not consider Wegovy cost-effective at the current U.S

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