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Furthermore, studies have shown that mitochondrial-targeted nanodrugs enhance the sensitivity of cancer cells to chemotherapy drugs by intervening in mitochondrial function, further emphasizing the emerging therapeutic strategy of reversing drug resistance through mitochondrial metabolic reprogramming [146]

3.3 UPF and anxiety 3.3.1 Background on known mechanisms of anxiety As of 2021, an estimated 4.4% of the global population experiences an anxiety disorder, making it the most prevalent mental disorder (111)