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Priming signals and cytokine milieu Neutrophil activation in PCOS unfolds within a pro-inflammatory cytokine microenvironment characterized by elevated concentrations of interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-), and interleukin-1 (IL-1)cytokines that collectively orchestrate neutrophil recruitment, priming, and effector activation [8]

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