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Hepatocyte Growth Factor/MET in Cancer Progression and Biomarker Discovery

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This activation significantly increased the Bcl-2-associated X protein (Bax)/B-cell lymphoma 2 (Bcl-2) ratio and cysteine-aspartate protease 3 (Caspase-3) expression, inhibited GPX4 and quinone oxidoreductase 1 (NQO1) expression, increased MDA levels, and promoted apoptosis, ferroptosis, and lipid peroxidation in NSC-34 cells

10.3390/cells11050851 262 LiY.LiuY.WuP.TianY.LiuB.WangJ.et al (2021c)

When elevation persisted on a second measurement, the association with incident solid cancer was strong, while a transient elevation carried no greater risk than a normal value