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GIP (glucose-dependent insulinotropic polypeptide) is another gut hormone that, like GLP-1, helps regulate blood sugar and appetite, so activating both pathways may provide additional benefits

This could improve the appearance of areas affected by vitiligo (4)

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Perampanel (FYCOMPA) Watch for increased aggressive behavior

Oral VK2735 (Viking Therapeutics) -- Phase 2# VK2735 is unique as the only dual GLP-1/GIP agonist with an oral formulation in clinical development: 12.2% weight loss at 13 weeks (oral tablet) 97% of treatment groups achieved at least 5% weight loss Oral Phase 3 expected Q3 2026 The injectable SC formulation achieved 14.7% at 13 weeks Oral Amycretin (Novo Nordisk) -- Phase 1# Novo Nordisk's oral amycretin demonstrated 13.1% weight loss at just 12 weeks, the highest early-stage oral result