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(2009) Extracellular signal-regulated kinase 1/2 activation counteracts morphine tolerance in the periaqueductal gray of the rat

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Rats tolerated doses far exceeding those used therapeutically without mortality or obvious adverse effects

Diets high in refined carbohydrates and low in protein or fiber can cause blood glucose fluctuations that trigger hunger signals despite adequate caloric intake

Nevertheless, several studies reported an increased risk of developing an anxiety disorder when assessed in the absence of a comorbid mental health disorder, or in combination with a depressive disorder, or in the setting of another comorbid mental health disorder (67, 79, 94, 98, 114, 115)