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Furthermore, methamphetamine blocks monoamine transporters and inhibits monoamine oxidase activity, crucial for the breakdown of neurotransmitters within the neurons

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While mutations of ETC proteins are rarely linked as a direct cause of PD (except for UQCRC1), impaired ETC proteins may not only lead to excessive ROS production, but also cause impeded mitophagy, -Syn aggregation, and apoptosis in PD pathogenesis