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Retatrutide is likely the better choice for patients who: Have severe obesity (BMI 40) and need maximum weight loss Have multiple metabolic complications (fatty liver, insulin resistance, osteoarthritis) Have already tried tirzepatide or a GLP-1/GIP dual agonist without adequate response retatrutide's glucagon component offers a genuinely different mechanism Don't mind weekly injections and want the highest available efficacy VK2735 may be the better choice for patients who: Are waiting for an oral option the oral Phase 3 could deliver GLP-1/GIP dual agonism without injection Have had tolerability issues with current injectables early data suggests a favorable GI profile Need 1822% weight loss rather than 28%+ adequate for moderate obesity Want a drug from a large pharma-backed pipeline (Viking's partnership discussions could shape commercial access) The most likely scenario: both drugs reach the market

Rg1 can play a role in restoring mitophagy (105), reducing mitochondrial dysfunction (106)

Low response rates are worrisome, as these limit the ability to monitor patient-reported outcomes and to incorporate patient perspectives into clinical decision making, and can bias aggregated data

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