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Moreover, besides the enhanced activity of fibroblasts, which are considered essential for collagen synthesis, tissue repair, and regeneration, there was also a potential rise in mast cell activation

These data led Werner to postulate that metal ions have two different kinds of valence: (1) a primary valence ( oxidation state ) that corresponds to the positive charge on the metal ion and (2) a secondary valence ( coordination number ) that is the total number of ligand-metal bonds bound to the metal ion

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