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comparing twice-daily short-acting exenatide with weekly exenatide [35], short-acting exenatide maintained its delayed gastric emptying effect after 14 weeks of continuous administration, whereas long-acting exenatides showed evidence of tachyphylaxis over days to weeks

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This is mainly due to the fact that research has traditionally focused on well-known stress molecules like SA or JA, or simply measured the activity of selected redox enzymes

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