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Patients who already have exceptionally high pyridoxine levels or signs of pyridoxine toxicity (such as sensory neuropathy) should not continue to receive high-dose supplementation until those symptoms resolve

Mechanism: Promotes angiogenesis, fibroblast migration, and collagen synthesis

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Hepatocyte growth factor modulates Interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases