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Patients frequently seek medical attention only after symptoms substantially impair quality of life, by which point tissue injury may be established, such as lupus nephritis in SLE, pericarditis in RA, or thromboembolic complications in Crohns disease [25, 26]

Dose-response relationships and timing considerations Optimal outcomes require proper dosing and timing strategies

The presence of these other types of crystal-related inflammation further emphasizes the value of identifying uric acid crystals as the cause of a particular patients arthritis whenever possible, to insure that the correct condition is being treated

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In our niclosamide solution approach they are not present and so cannot exert any deleterious equilibrating effects, i.e., the high niclosamide solution concentration is preserved