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It is well-tolerated in animal and early clinical studies, even at multi-milligram doses [12]

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors

The research supporting its use

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Notice that the strongest-designed study in the entire pair (the human dry-eye RCTs) tests the wrong molecule for the wrong use if your interest is injectable soft-tissue recovery