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Nicotine causes a rush of adrenaline and dopamine in humans

In some individuals, exposure to propylene glycol aerosols in concentrations found in e-cigarettes has been shown to cause irritation to the eyes and throat

If in the assessment step a health care professional uncovers a smoker who is unwilling to quit, the American College of Chest Physicians recommends that the professional who is counseling the smoker work jointly with the patient to identify and define what is called the five Rs: Relevance, Risk, Rewards, Roadblocks, and Repetition

But it runs even deeper than that, I think

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