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Trials of combination NRT were used to inform this estimate because: (1) randomized trials of a high-dose nicotine patch are not available to inform the projected treatment size, and (2) similar to nicotine patch, combination NRT also allows upward titration to reach satiety

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Retailers who sell tobacco products to anyone under 21 face significant penalties

Cloves also contain an active ingredient that traditional cigarettes dont contain eugenol

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