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Study settings Study settings include a smoking cessation treatment clinic at the Centre for Addiction and Mental Health (CAMH) in Toronto, Canada, and a smoking cessation treatment clinic at the University of Ottawa Heart Institute (UOHI) in Ottawa, Canada

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In smokers, a single dose of the xanthine oxidase inhibitor allopurinol restores the acetylcholine-induced endothelium-dependent relaxation response in forearm arteries to nonsmoker levels but does not affect the endothelium-dependent relaxation response in nonsmokers [73]

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