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The study suggests that activation of the A2BAR on alternatively activated macrophages is essential in the development of pulmonary fibrosis and pulmonary hypertension (138)

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Smoking, cigarette smoke exposure, tobacco smoke or pollutants in the air contact directly with the airway, through the way to the lungs, causing a variety of airway diseases, such as COPD, asthma, cystic fibrosis and lung cancer

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