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The pathophysiological effects of the other trace metals in cigarette smoke have previously been reviewed (Chiba and Masironi, 5, 6 for both ECIG-generated aerosol (4 g/cig equivalent) and cigarette smoke (8 g/cig), it is necessary to mention the fact that Al accumulation in neural tissue may be correlated with Alzheimer's disease (Tomljenovic, 5 and their relationship to estimated maximum allowed inhalation shown in Table 7, it is unlikely that the other trace metals detected in ECIG-generated aerosol pose any serious pathological risks

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