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However, obtaining and culturing human primary alveolar macrophages is challenging due to their deep location within the lung and their terminal differentiation status, which was out of scope for this study

Not only does this mean we might finally get an answer to the cryptic and therefore appropriately Lynch-ian finale of the original series (which Fire Walk with Me couldnt resolve, since it was a prequel), it also means that well get some new Lynch material after what will then be a ten-year-long dry spell since the nightmare machine known as Inland Empire

1990 Fall;17(3):329-45

However, the transition period can be challenging, as the body adjusts to the absence of nicotine

Wu et al., 2014