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Food and Drug Administration has established a list of chemicals that are called HPHCs - Harmful and Potentially Harmful Constituents - that are in tobacco products that cause or could cause harm to smokers or nonsmokers

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Control 23 , 133139 (2014)

A study published in JAMA Internal Medicine in 2014 concluded: "E-cigarette use by smokers was not followed by greater quitting, or reduction in consumption one year later." Another 2015 study in the journal Addiction found that daily use of e-cigarettes seemed to be associated with an increase in the rate of attempts to quit smoking and less smoking, though not increased rates of quitting