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The up-regulation of the anti-apoptotic proteins Bcl-2 and Mcl-1 in these cells was also mediated by the PI 3 K-Akt signaling pathway (Wang et al

Am J Physiol Heart Circ Physiol 317(2):H445Hh59 Hom S, Chen L, Wang T, Ghebrehiwet B, Yin W, Rubenstein DA (2016) Platelet activation, adhesion, inflammation, and aggregation potential are altered in the presence of electronic cigarette extracts of variable nicotine concentrations

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surgeon general has concluded that the burden of death and disease from tobacco use in the United States is overwhelmingly caused by cigarettes and other combusted tobacco products