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In an effective smoking cessation intervention study of hip or knee replacement patients, the overall complication rate of the study patients within 4 weeks was 18% in the intervention group and 52% in the control group, with a relative risk of 0.34 15

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These include those with early exposure to nicotine, have a genetic predisposition to the condition, people with a family history of nicotine abuse or substance use, and those experiencing peer pressure, depression, and other mental illnesses