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Established distribution networks are important for allowing changes in supply (see Joossens and Raw, 1998, p
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Interestingly, like nicotine [7], THC (and namely, activation of cannabinoid receptors 1 and 2) has also been shown to play in important role in the regulation of transient lower esophageal sphincter relaxations, as well as lower esophageal pressure [8, 9], further supporting vaping as the trigger of our patients presentation
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