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According to the Centers for Disease Control and Prevention (CDC), Overdoses involving opioids killed nearly 69,000 people in 2020, and over 82% of those deaths involved synthetic opioids

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As /Film's Jeremy Smith pointed out: "Though Mann's 'Ali' was generally well-received when it was released in 2001, critics complained that it essentially told the same 'Rumble in the Jungle' story as Leon Gast's Oscar-winning 1996 documentary, 'When We Were Kings.' In doing so, they overlooked what is easily the most technically detailed and accurate dramatization of 'the sweet science' ever put to film

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The strength of this study is inclusion of participants from all levels of the health system in four geographically distinct provinces of Vietnam, increasing its generalisability