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The age, gender and period of smoking affect degree of vulnerability to the disease with occurrence common among the old, the males and lifelong smokers

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A 2022 Cochrane review, which is considered the gold standard for the assessment of research into the efficacy and safety of safer nicotine products, has stated that There was moderatecertainty evidence that heated tobacco users have lower exposure to toxicants/carcinogens than cigarette smokers

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