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Keywords: osteoarthritis, cigarette smoking, electronic cigarette, synovitis, immune dysregulation, inflammasome, NF-B, microRNA Introduction Osteoarthritis (OA) is a major cause of chronic pain and disability around the world, and it has become an increasing public health problem

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The study , conducted by KPMG LLP, examined the Region of the Americas (excluding the United States) and found that the region now has the highest global incidence of illicit tobacco, driven by steep tax increases and regulatory pressures that have pushed consumers toward cheaper illegal products