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Studies show that at least half of all adult smokers try to quit each year, and VLN cigarettes give them an alternative that tastes, smells and burns like a cigarette but greatly reduces their nicotine consumption, 22nd Century CEO James Mish said

HIFs are protective in the short-term, but chronic HIF stabilization in the RPE can exert detrimental effects [15,16,17,18], from which the metabolic shift is most relevant for the present study

PMID 16723674

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